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Children are often more vulnerable than adults to the effects of environmental contaminants found in their everyday environments. Their dynamic growth and unique interactions with the built, natural, and social environments may result in a greater susceptibility to chemical and n...

Recordings of neural network activity in vitro are increasingly being used to assess the development of neural network activity and the effects of drugs, chemicals and disease states on neural network function. The high-content nature of the data derived from such recordings can ...

Volunteered geographic information (VGI) can be used to identify public valuation of ecosystem services in a defined geographic area using photos as a representation of lived experiences. This method can help researchers better survey and report on the values and preferences of s...

Through the food and water they ingest, the air they breathe, and the consumer products with which they interact at home and at work, humans are exposed to tens of thousands of chemicals, many of which have not been evaluated to determine their potential toxicities. In recent yea...

Changing emission patterns across the globe are resulting in heterogeneous changes in tropospheric chemical composition and likely altering the long-range transport of air pollutants and their impact at receptor regions. In this study, we combine results from multi-decadal simula...

Comprehensive presentation to share and discuss transdisciplinary solutions to challenges faced in sustainable management of urban water. Present research on urban water challenges and solutions, followed by an open panel discussion about overcoming multiple challenges by integra...

Screening methods for detecting potential endocrine disrupting chemicals rely chiefly on transactivation assays targeting nuclear receptors such as the estrogen (ER) and androgen receptors (AR). These assays are predominately human-based; yet environmental exposure can affect div...

Nearshore conditions drive phenomena like harmful algal blooms (HABs), and the nearshore and coastal margin are the parts of the Great Lakes most used by humans. To assess conditions, optimize monitoring, and evaluate management options, a model of nearshore nutrient transport an...

Nitrogen (N) presents an important challenge for sustainability due to its role in providing goods and services to society, since release of N beyond its intended use has many negative consequences. Several systems modeling approaches have been developed to understand the tradeof...

A quantitative adverse outcome pathway (qAOP) consists of interrelated computational models that together describe the mechanistic biology linking a toxicant-induced, molecular-level initiating event (MIE) with an adverse outcome at the level of individuals or populations. A qAOP...

Modeling the magnitude and distribution of sediment-bound pollutants in estuaries is often limited by incomplete knowledge of the site and inadequate sample density. To address these modeling limitations, a decision-support tool framework was conceived that predicts sediment cont...

The wind energy absorbed in the global boundary layer (GBL, 900 mb surface) is the basis for calculating the wind emergy input for any system on the Earth’s surface. Estimates of the wind emergy input to a system depend on the amount of wind energy dissipated, which can have a ra...

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Exposures to chemical and non-chemical stressors from children&rsquo;s environments during early development may contribute to differences in their health and well-being outcomes. Children from American Indian tribes may have a disproportionate burden of these stressors from thei...

Choosing where to sample for aquatic invasive species (AIS) is a daunting challenge in the Laurentian Great Lakes. Management resources are finite hence it is important that monitoring efforts concentrate on those sites with the highest risk of introduction based on transparent c...

Engineered nanomaterials (ENMs) represent a new regulatory challenge because of their unique properties and their potential to interact with ecological organisms at various developmental stages, in numerous environmental compartments. Traditional toxicity tests have proven to be...

Cumulative risk assessments (CRAs) address combined risks from exposures to multiple chemical and nonchemical stressors and may focus on vulnerable communities or populations. Significant contributions have been made to the development of concepts, methods, and applications for C...

StatCharrms is a graphical user front-end for ease of use in analyzing data generated from OCSPP 890.2200, Medaka Extended One Generation Reproduction Test (MEOGRT) and OCSPP 890.2300, Larval Amphibian Gonad Development Assay (LAGDA). The analyses StatCharrms is capable of perfor...

Cumulative risk assessment (CRA) methods, which evaluate the risk of multiple adverse outcomes (AOs) from multiple chemicals, promote the use of a conceptual site model (CSM) to integrate risk from relevant stressors. The Adverse Outcome Pathway (AOP) framework can inform these r...

Out-of-hospital sudden unexpected deaths (OHSUD) are natural deaths that occur without obvious underlying causes and account for nearly 1 in 6 deaths in the United States. Ambient air pollution is known to be causally related to overall mortality, therefore, we hypothesized that ...

A number of putative AOPs for several distinct MIEs of thyroid disruption have been formulated for amphibian metamorphosis and fish swim bladder inflation. These have been entered into the AOP knowledgebase on the OECD WIKI.

Introduction: Metabolic syndrome (MeTS) is the cluster of several clinical symptoms that together represent the strongest risk factor for cardiovascular disease. The prevalence of MeTS in adolescents is difficult to estimate given that there are several, but no agreed upon defini...

Engineered nanomaterials (ENM) are a growing aspect of the global economy, and their safe and sustainable development, use and eventual disposal requires the capability to forecast and avoid potential problems. This review is concerned with the releases of ENM into the environmen...

A tremendous amount of data on environmental stressors has been accumulated in exposure science, epidemiology, and toxicology, yet most of these data reside in different silos. The Adverse Outcome Pathway (AOP) framework was developed as an organizing principle for toxicological ...

Background/Aim: A previous analysis suggested that U.S. counties with higher county-level prevalence of chronic conditions had stronger associations of mortality with fine particulate matter (PM2.5). This study assesses the modification of the effect of PM2.5 on daily hospitaliz...